The focus of my research is on the development of statistical methods for single-cell RNA-seq (scRNA-seq) and chromatin interaction (Hi-C) data analysis, and their application to the genetic dissection of complex diseases and traits. In particular, I have developed single-cell aggregated clustering methods (implemented in software SAFE-clustering and SAME-clustering) for flexible, accurate and robust clustering scRNA-seq data. In addition, I also work on batch effect correction for single-cell RNA-seq data, which takes advantages of cell type/cluster information to guide supervised mutual nearest neighbor detection (SMNN method). More recently, I worked on the statistical framework for Hi-C peak calling (MUNIn program), and identifying and characterizing cardiovascular cell types in mouse and the wounding-related cell dynamics in zebrafish.


2020 - present: Research Assistant Professor
Department of Pathology and Laboratory Medicine
McAllister Heart Institute
University of North Carolina, Chapel Hill

2016 - 2020: Postdoctoral Fellow
Advisor: Dr. Yun Li
Department of Genetics
University of North Carolina, Chapel Hill

2011 - 2016: Graduate/Ph.D. Student
Major: Biochemistry and Molecular Biology
Advisor: Dr. Suhua Shi
School of Life Science
Sun Yat-sen University, Guangzhou, China

2007 - 2011: Undergraduate/B.S. Student
Major: Biotechnology
School of Life Science
Sun Yat-sen University, Guangzhou, China


2015 - 2017 Academic Scholarship Award of Chang Hungta Science Foundation, Sun Yat-sen University
2015 National Scholarship Award for Graduate Students, China
2015 Wang Bosun Ecology Scholarship Award, Sun Yat-sen University
2015 Second Prize for Outstanding Graduate Award, State Key Laboratory of Biocontrol, Sun Yat-sen University
2008 - 2010 First Prize Scholarship Award for Undergraduate Students, Sun Yat-Sen University


Office: Medical Biomolecular Research Bldg., 111 Mason Farm Road, Chapel Hill, NC 27599